Endocrine Abstracts

Introduction: Tumor-induced osteomalacia (TIO) is a paraneoplastic syndrome due to an overproduction of fibroblast growth factor 23 (FGF23) by small and benign mesenchimal tumors. FGF23 increase causes hypophosphatemia, osteomalacia and muscle weakness. TIO is usually cured by tumour resection, but neoplasms may be unidentifiable/unresectable or the patient may refuse surgery. In these cases, medical treatment with high doses of oral phosphate and calcitriol is mandatory, even...

Background: Glucose metabolism derangements (GMD) and thyroid nodules (TN) are the most frequent endocrine disorders. A relationship between these conditions has been suggested, but data are still controversial and no evidence was reported regarding sex differences.Aim: To evaluate the distribution of impaired fasting glucose (IFG), normal glucose tolerance (NGT), impaired glucose tolerance (IGT), type 2 diabetes (T2DM) and TN according to sex.<p cla...

Introduction: Magmas encodes for an integral constituent of the TIM23 translocase complex located in the mitochondrial inner membrane that drives proteins from the intermembrane space into the mitochondrial matrix by functionally interacting with Tim14. We previously demonstrated that Magmas silencing is able to sensitize ACTH-secreting mouse pituitary adenoma cells to pro-apoptotic stimuli, reduce DNA synthesis, accumulate cells in G0/G1 phase with concomitant decrease in S p...

Introduction: Typical and Atypical bronchial carcinoids (TBC and ABC) are rare neuroendocrine neoplasms (NEN). TBC are low grade and well-differentiated NEN often with indolent clinical behavior, slow growth, rare extra-thoracic metastases, and with a long survival following surgical resection. Conversely, ABC have often a worse prognosis with a greater tendency to metastasize and recur. A better understanding of TBC and ABC genetic background would help in evaluating prognosi...

BackgroundPapillary thyroid carcinoma (PTC) is the most frequent thyroid malignant neoplasm. American Thyroid Association (ATA) guidelines don’t specify how to follow-up low-risk PTC patients not receiving radioiodine therapy (RAI) after total thyroidectomy (TT). Indeed, there is no consensus among authors regarding the interpretation of thyroglobulin (TG) levels and ultrasound neck (US) findings during follow-up in these settings.<p class="abst...

IntroductionTypical bronchial carcinoids (TBC) are rare well-differentiated neuroendocrine neoplasms (NEN) of the lung whose management can still be very challenging. In fact, the gold-standard treatment for TBC is total resection of the primary tumour; however, in case of metastatic disease adjuvant therapy with the mTOR inhibitor everolimus (eve) might be recommended. Unfortunately, prognosis may be very poor in cases showing moderate response rates to...

BackgroundThyroid diseases and diabetes are the two most common endocrinopathies. A relationship between these two conditions is suggested by many studies, as diabetic population seems to present increased thyroid impairment. However, clinical data are still very sparse.AimTo evaluate thyroid morphologic characteristics among patients with different glucose tolerance status.Material and...

Introduction: Thalassaemia syndromes are a group of inherited haemolytic disorders determining chronic anaemia, iron overload and organ damage (through the production of ROS), necessitating of iron chelation therapy. Nowadays, there is scant knowledge on hypercalciuria in thalassaemic Western patients. Therefore, aim of our study was evaluating the prevalence of hypercalciuria and identifying risk factors and clinical consequences associated with its development.<p class="...

Introduction: First-generation SRL (fg-SRL) represent the treatment of choice in acromegaly patients with post-neurosurgical adenomatous remnant and GH-hypersecretion. Anyway, approximately 60% of patients do not achieve adequate disease control. The main predictors of resistance include male sex, young age, invasiveness of the lesion and its hyperintensity on T2-weighted MRI scans; but also, SSTR2 expression, the cytokeratin pattern, Ki-67 and the presence of AIP gene mutatio...

Introduction: Acromegaly patients (ACRO) show increased morbidity that affects health and quality of life (QoL). Elderly ACRO are going to increase in the next few years, but evidence regarding their management is lacking.Aim: To evaluate physical, functional and cognitive performances of elderly ACRO and the relationship with QoL.Methods: Multicenter case-control study conducted on 42 older ACRO (≥ 65 years) compared to an a...